Perinatal Pharmacology
نویسندگان
چکیده
1 Department of Development and Regeneration, KU Leuven and Neonatal Intensive Care Unit, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium 2Department of Surgery, Section of Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, University of Cagliari, Cagliari, Italy 3 Departments of Pediatrics, Pharmacology, Physiology, and Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington DC, USA 4 Intensive Care, Erasmus MC-Sophia Children’s Hospital, Rotterdam, The Netherlands 5 Department of Pediatric Pharmacology, University Children’s Hospital Basel, Basel, Switzerland 6Department of Clinical Pharmacy and Pharmacotherapy, Heinrich Heine University of Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany
منابع مشابه
Perinatal growth restriction decreases diuretic action of furosemide in adult rats.
Perinatal growth restriction programs higher risk for chronic disease during adulthood via morphological and physiological changes in organ systems. Perinatal growth restriction is highly correlated with a decreased nephron number, altered renal function and subsequent hypertension. We hypothesize that such renal maladaptations result in altered pharmacologic patterns for life. Maternal protein...
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The developmental effects of exposure to various doses of buprenorphine, methadone, or water during the perinatal period were studied in the rat. Rats were exposed to buprenorphine (0.3, 1.0, or 3.0 mg/kg/day), methadone (9 mg/kg/day), and/or water prenatally, postnatally, or both pre- and postnatally, via maternally implanted osmotic minipumps. Fetal and maternal mortality and morbidity were a...
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A large body of experimental evidence indicates that over-activation of excitatory amino acid (EAA) receptors may mediate irreversible neuronal injury in a variety of pathologic settings including cerebral ischemia, and that the developing brain may be particularly susceptible to the adverse effects of EAA receptor overactivation. In this article, we review current information about EAA recepto...
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This article reviews mechanisms by which local anesthetics may compromise the fetus during conduction analgesia in obstetrics. In addition to presenting pertinent information about perinatal pharmacology of local anesthetics, the author discusses comparative effects of 2-chloroprocaine and amide-linked compounds. Recommendations are made for prevention of maternal hypotension and local anesthet...
متن کاملExcitotoxicity as a Common Mechanism for Fetal Neuronal Injury with Hypoxia and Intrauterine Inflammation.
Excitotoxicity is a mechanism of neuronal injury, implicated in the pathogenesis of many acute and chronic neurologic disorders, including perinatal brain injury associated with hypoxia-ischemia and exposure to intrauterine inflammation. Glutamate, the primary excitatory neurotransmitter, signals through N-methyl-d-aspartic acid (NMDA)/α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) rec...
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عنوان ژورنال:
دوره 2014 شماره
صفحات -
تاریخ انتشار 2013